If you haven't heard of or listened to this lecture, it is well worth it... and not in a Tuesdays with Morrie, cloying kind of way.
The background is this: "The Last Lecture" is a university tradition. A professor will be asked to deliver a talk as if it were the last lecture she/he would ever give - an opportunity to reflect on a life lived, pass on advice and speculate on what it all means. Randy Pausch, a professor at Carnegie Mellon was diagnosed with pancreatic cancer last fall and delivered his own last lecture, Really Achieving Your Childhood Dreams, one month later. A longer book version is about to be published.